The Treatment of Mycosis with Imidazole Derivatives

Inhaltsverzeichnis

• 1 Introduction.
• 1.1 Antimicrobial Therapy.
• 1.2 Microbial Diseases of the Skin and Mucous Membranes.
• 1.3 Antimicrobial Drugs for Local Application.
• 2 Broad-Spectrum Antimicrobials for Local Application.
• 2.1 Preliminary Remarks.
• 2.2 Disinf ectants and Antiseptics.
• 2.3 Antibiotics.
• 2.4 Chemotherapeutic Agents.
• 2.5 Imidazole Derivatives with Antimicrobial Action.
• 3 Econazole.
• 3.1 General.
• 3.2 Chemical Structure.
• 3.3 Physical Properties.
• 3.4 Antimicrobial Spectrum.
• 4 General Microbiology of Imidazole Derivatives for Local Application.
• 4.1 Preliminary Remarks.
• 4.2 Modeof Action.
• 4.3 Resistance and Tolerance.
• 4.4 Interactions with Other Compounds.
• 4.5 Bioavailability Studies.
• 5 Therapeutic Use of Imidazole Derivatives in Animals (Experimental Therapy).
• 5.1 Local Application.
• 5.2 Systemic Application.
• 6 General Pharmacology of the Imidazole Derivatives in Man and Animals.
• 6.1 Pharmacologic Properties (Apart from Antimicrobial Action) ...
• 6.2 Absorption, Excretion, and Metabolism in Animals.
• 6.3 Absorption, Excretion, and Metabolism in Man.
• 6.4 Sensitization.
• 6.5 Anaphylactoid Activity.
• 7 Toxicology of the Imidazole Derivatives.
• 7.1 Preliminary Remarks.
• 7.2 SystemicToxicity.
• 7.3 LocalToxicity.
• 8 Clinical Pharmacology of Topical Antimicrobials with Special Regard to the Imidazole Derivatives.
• 8.1 Preliminary Remarks.
• 8.2 Physical Properties.
• 8.3 SkinTolerance.
• 8.4 Sensitization.
• 8.5 Photosensitizing Reactions.
• 8.6 Interactions with Substances on the Skin Surface.
• 8.7 Penetration and Absorption.
• 8.8 Systemic Administration.
• 8.9 Use in Veterinary Mediane and the Food Industry.
• 8.10 Special Clinical Pharmacologic Considerations in the Local Application of Antimicrobials.
• 8.11 Clinical Pharmacology of the Preparation.
• 9 Microbial Infections in Man.
• 9.1 General.
• 9.2 Increase in Microbial Infections of Body Surfaces.
• 9.3 Saprophytes and Parasites on Body Surf aces.
• 9.4 Mixed and Double Inf ections of Body Surf aces.
• 10 Mycoses.
• 10.1 Etiology of Mycoses.
• 10.2 The Increase in Mycoses.
• 10.3 Classification of Mycoses.
• 10.4 Mycoses of the Skin and Mucous Membranes.
• 10.5 Mycoses of the Female Genitalia.
• 10.6 Systemic Mycoses.
• 10.7 General Principles in the Treatment of Mycoses.
• 11 Systemic Administration of Antimycotically Active Imidazole Derivatives in Man.
• 12 Local Application of Antimycotically Active Imidazole Derivatives in Man.
• 12.1 Application to the Outer Skin.
• 12.2 Application to the Mucous Membranes.
• 13 Combined Use of Imidazole Derivatives and Glucocortoids for the Local Treatment of Skin Diseases.
• 13.1 Preliminary Remarks.
• 13.2 Combination of Antibiotics with Glucocortoids.
• 13.3 Salicylic Acid, Haloprogin, Clioquinol, Chlorquinaldol, and Triclosan.
• 13.4 Imidazole Derivatives and Glucocortoids.
• 13.5 Indications for the Combined Use of Imidazole Derivatives and Glucocorticoids.
• 14 Assessment of Mycoses in Various Branches of Mediane.
• 14.1 Dermatology.
• 14.2 Gynecology.
• 14.3 Pediatrics.
• 14.4 Stomatology.
• 14.5 Otolaryngology.
• 14.6 Otorhinolaryngology.
• 14.7 Proctology.
• 14.8 Urology.
• 14.9 Internal Mediane.
• 14.10 Orthopedics.
• 14.11 Surgery, Intensive Care, Anesthesiology.
• 15 Concluding Remarks.
• 16 References.
• 17 Subject Index.